課程名稱 |
發育生物學 Developmental Biology |
開課學期 |
112-2 |
授課對象 |
學程 幹細胞與再生醫學學程 |
授課教師 |
劉逸軒 |
課號 |
AniSci4010 |
課程識別碼 |
606 64090 |
班次 |
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學分 |
3.0 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
星期二6,7,8(13:20~16:20) |
上課地點 |
畜三 |
備註 |
總人數上限:20人 |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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課程概述 |
This course offers an in-depth exploration of developmental biology with a primary focus on vertebrates. We examine how a single fertilized egg develops into a complex organism composed of hundreds of specialized cell types structured in precise ways. This exploration not only will cover the intricate processes of biological development but also emphasize the cellular and molecular mechanisms underpinning these phenomena. A unique aspect of this course is its integration of theoretical knowledge with practical application. We will delve into the philosophy, general strategies, and cutting-edge technologies currently employed in the study of embryonic development. By the end of the course, students comprehend key models and seminal discoveries in the field, can interpret current literature, and possess vocabulary to articulate concepts and processes underlying vertebrate embryogenesis. The knowledge and analytic skills students acquire create a strong foundation for advanced study in developmental biology and related life science disciplines. |
課程目標 |
By the end of this course, students are expected to:
1. Terminological Proficiency: Gain familiarity with the specific terminologies and definitions used in developmental biology, forming a foundational language for further study and discussion.
2. Anatomical Understanding: Acquire a general understanding of the origins and development of each anatomical structure, including insight into the transitional phenomena that occur during development.
3. Mechanistic Insight: Develop a thorough understanding of the cellular and molecular mechanisms that drive these developmental processes, providing a comprehensive view of how complex biological systems evolve and function.
4. Research Comprehension: Attain a deep comprehension of the philosophical approaches, general strategies, and basic techniques utilized in developmental biology research, equipping students to critically analyze and understand scientific inquiries and findings in this dynamic field.
Through this course, students will not only gain a robust understanding of developmental biology from a vertebrate perspective but also develop the skills necessary to engage with and contribute to ongoing research in this ever-evolving scientific domain.
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課程要求 |
It is recommended that you have finished courses for Genetics, Molecular Biology and Cell Biology. |
預期每週課後學習時數 |
6 hours |
Office Hours |
另約時間 備註: Friday 9-10:00 am. Appointment via email is strongly encouraged. |
指定閱讀 |
1.Horder, Tim (November 2010) History of Developmental Biology. In: Encyclopedia of Life Sciences (ELS). John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0003080.pub2
2. Keiko U Torii. Two-dimensional spatial patterning in developmental systems. Trends Cell Biol . 2012 Aug;22(8):438-46. doi: 10.1016/j.tcb.2012.06.002. [PMID: 22789547] |
參考書目 |
1. SF Gilbert, 2014. Developmental Biology. Sinauer Associates, 10th Edition, ISBN 978-0- 87893-978-7.
2. MJF Barresi, SF Gilbert. 2019. Developmental Biology. Sinauer Associates. 12th edition, ISBN 978-1605358222 (hard cover) or ISBN 978-1605358246 (paper back).
3. MJF Barresi, SF Gilbert. 2023. Developmental Biology. Oxford University Press. 13th edition, ISBN 978-0197574591 (hard cover) or ISBN 978-0197574614 (paper back).
4. Publications cited in the class. |
評量方式 (僅供參考) |
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針對學生困難提供學生調整方式 |
上課形式 |
以錄音輔助, 以錄影輔助, 提供學生彈性出席課程方式 |
作業繳交方式 |
書面報告取代口頭報告 |
考試形式 |
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其他 |
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週次 |
日期 |
單元主題 |
Week 1 |
2/20 |
00. The development of developmental biology |
Week 2 |
2/27 |
01. Research principles I: questions and classical methods |
Week 3 |
3/05 |
02. Research principles II: developmental genetics |
Week 4 |
3/12 |
03. Cell-cell communication: inputs for gene regulatory networks |
Week 5 |
3/19 |
04. Fertilization: the beginning of life |
Week 6 |
3/26 |
05. Early development I: amphibians |
Week 7 |
4/02 |
06. Early development II: teleost and amniotes |
Week 8 |
4/09 |
Midterm exam |
Week 9 |
4/16 |
07. Ectoderm I: CNS development |
Week 10 |
4/23 |
08. Ectoderm II: neural crest and axonal specification |
Week 11 |
4/30 |
09. Mesoderm I: paraxial mesoderm and primaxial organization |
Week 12 |
5/07 |
10. Mesoderm II: lateral plate mesoderm and the circulatory system |
Week 13 |
5/14 |
11. Development of tetrapod limb |
Week 14 |
5/21 |
12. Gonadal development I: germ cells |
Week 15 |
5/28 |
13. Gonadal development II: sex determination |
Week 16 |
6/04 |
Final exam |
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